Cellular Biology Contributions of Ion Channel Currents to Ventricular Action Potential Changes and Induction of Early Afterdepolarizations During Acute Hypoxia
نویسندگان
چکیده
Methods and Results: We incorporated all published data on the effects of hypoxia on the late Na current (INa-L), the fast Na current (INa), the basal L-type Ca 2 channel current (ICa-L), and the slow (IKs) and rapid components of the delayed rectifier K -current (IKr) in the absence and presence of -adrenergic receptor ( -AR) stimulation into the Luo–Rudy model of the action potential. Hypoxia alone had little effect on the action
منابع مشابه
Contributions of ion channel currents to ventricular action potential changes and induction of early afterdepolarizations during acute hypoxia.
RATIONALE Variability in delivery of oxygen can lead to electric instability in the myocardium and the generation of arrhythmias. In addition ischemic heart disease and angina are associated with an increase in circulating catecholamines that further increases the risk of developing ventricular tachyarrhythmias. OBJECTIVE We investigated the net effects of acute hypoxia and catecholamines on ...
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